Time: Thursday 21 Jan 2021 at 19:30
Due to the COVID-19 pandemic, this event will be delivered online. More details can be found here.
TITLE: Life in the balance: How protein quality control governs health and disease
E
very cell in our body exists as part of a hugely sophisticated machinery that strives to prolong life. Our cells must work optimally under stressful conditions and be able to overcome challenges. These stresses arise with every little change of our environment (like eating lunch or exercising) and cells adapt to these stresses through quality control mechanisms. In the first part of this talk we will see how these same mechanisms govern the manifestation of disease using cancer and neurodegeneration as examples. In the second part we will have a look at the diverse landscape of disciplines needed to design a new drug, the challenges behind targeting these quality control mechanisms to combat disease and how a clinical trial for such a medicine is designed.
SPEAKER: Dimitrios Doultsinos
Dimitrios Doultsinos is an Associate Research Fellow in Prostate Oncology at the Department of Surgery at the University of Oxford and the John Radcliffe Hospital. Dimitrios has worked in various NHS Trusts and has a background in Neurology and Oncology with an expertise in small molecule drug development, clinical trial design and cancer biology. Currently he is characterising a new drug candidate for prostate cancer and explores how cancer cell biology can lead to treatment resistant disease.